Current studies
HIV studies
Vogue
VOGUE seeks to evaluate the efficacy, safety, and tolerability of using an oral once-daily 2-drug regimen compared to an oral once-daily 3-drug regimen as a first line regimen for the treatment of HIV-1 patients. Patients will be randomised to either: Dovato or Biktarvy
Principal investigator: Prof Alan Winston
FOST Switch
Evaluating efficacy and safety of switching a boosted protease inhibitor to fostemsavir in PLWH with limited therapeutic options
FOST Switch - Health Research Authority (hra.nhs.uk)
Principal investigator: Prof Alan Winston
DORDOL
DORDOL aims to investigate the efficacy of switching patients on triple cART to dual cART; to reduce exposure to side effects whilst providing the same quality of care.
DORDOL - Health Research Authority (hra.nhs.uk)
The RIO trial
A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART
The RIO Trial - Health Research Authority (hra.nhs.uk)
Principal investigator: Prof Sarah Fidler
Funder: Bill & Melinda Gates Foundation
STRIVE
An open-label dose-escalation study evaluating the safety, pharmacokinetics and antiviral activity of IMC-M113V in HLA-A*02:01 positive subjects with chronic HIV infection who are virologically suppressed
Phase 1/2 study of IMC-M113V in virologically suppressed chronic HIV - Health Research Authority
Principal investigator: Dr Borja Mora-Peris
POPPY Waves 4 & 5
A prospective, observational study to examine the effects of ageing on the clinical outcomes of people living with HIV in England and Ireland - Waves 4 and 5 POPPY 4 & 5 – ‘Pharmacokinetic and Clinical Observations in People over Fifty Waves 4 and 5
POPPY Waves 4 & 5 - Health Research Authority (hra.nhs.uk)
Principal investigator: Prof Alan Winston
PRePaRe
To assess the use of PrEP among people newly diagnosed with HIV, to understand the circumstances under which these HIV infections occurred and to estimate the prevalence of HIV drug resistance in this group of people
Principal investigator: Dr Borja Mora-Peris
VIRIAS
Viral reservoir integration analysis study; Sub-study of Evolutionary Dynamics of Viral Reservoir Cells.
VIRIAS - Health Research Authority
Principal Investigator: Prof Sarah Fidler
CASCADE
Qualitative observational study of the experiences and needs of people with recently acquired HIV
Principal investigator: Prof Sarah Fidler
Sexual Health studies
TREP AB
Oral and Neuro-Penetrative Alternative Antibiotics for Patients with Syphilis.
Trep-AB - Health Research Authority
Principal Investigator: Dr Fareed Shiva
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