Professor Jonathan Weber Professor and honorary consultant physician

Background

Professor Jonathan Weber is the Jefferiss Professor of Genitourinary Medicine and Communicable Diseases at Imperial College London, and an honorary consultant physician at St Mary’s Hospital. He trained at Cambridge University and St Bartholomew’s Hospital, the Institute of Cancer Research and the Royal Postgraduate Medical School, before establishing the academic department of genitourinary medicine, attached to the Jefferiss Wing, in 1991. He has researched HIV infection and AIDS since 1982, developing combination antiretroviral therapy in the 1990s. He is now working on HIV prevention through vaccine development.

Expertise

Human retroviral infections, HIV, HTLV, sexually transmitted diseases

Research & publications

English, S., Katzourakis, A., Bonsall, D., Flanagan, P., Duda, A., Fidler, S., Weber, J., McClure, M., Spartactis, T.S., Phillips, R., et al.(2011) Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants. Retrovirology, 8 (1),  54.  PMID: 21736738   

Erlwein, O., Robinson, M.J., Dustan, S., Weber, J., Kaye, S. & McClure, M.O. (2011) DNA extraction columns contaminated with murine sequences. PLoS ONE 2011, 6 (8), e23484. PMID: 21876752  

Fox, J., White, P.J., Weber, J., Garnett, G.P., Ward, H. & Fidler, S. (2011) Could we, should we? Yes. AIDS, 25 (14), 1801.  PMID: 21876391   

Frater, J., Ewings, F., Hurst, J., Brown, H., Robinson, N., Fidler, S., Babiker, A., Weber, J., Porter, K. & Phillips, R.E. (2013) HIV-1 specific CD4 responses in primary HIV-1 infection predict disease progression in the SPARTAC trial. AIDS, 28 (5), 699-708. PMID: 24549145    

Gall, A., Kaye, S., Hué, S., Bonsall, D., Rance, R., Baillie, G.J., Fidler, S.J., Weber, J.N., McClure, M.O. & Kellam, P. (2013) Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters. Retrovirology, 10 (1), 8.  PMID:  23331949    

García, F., Bernaldo de Quirós, J.C., Gómez, C.E., Perdiguero, B., Nájera, J.L., Jiménez, V., García-Arriaza, J., Guardo, A.C., Pérez, I., Díaz-Brito, V., Conde, M.S., González, N., Alvarez, A., Alcamí, J., Jiménez, J.L., Pich, J., Arnaiz, J.A., Maleno, M.J., León, A., Muñoz-Fernández, M.A., Liljeström, P., Weber, J., Pantaleo, G., Gatell, J.M., Plana, M. & Esteban, M. (2011) Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02). Vaccine, 29 (46), 8309–16.  PMID: 21907749  

Hamlyn, E., Ewings, F.M., Porter, K., Cooper, D.A., Tambussi, G., Schechter, M., Pedersen, C., Okulicz, J.F., McClure, M., Babiker, A., Weber, J. & Fidler, S., on behalf of the INSIGHT SMART and SPARTAC Investigators (2012) Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. PLoS ONE,7 (8), e43754. PMID: 22952756  

Hamlyn, E., Fidler, S., Stöhr, W., Cooper, D.A., Tambussi, G., Schechter, M., Miro, J.M., McClure, M., Weber, J., Babiker, A. & Porter, K., for SPARTAC Trial Investigators (2013) Interleukin-6 and D-dimer levels at seroconversion as predictors of HIV-1 disease progression. AIDS, 28(6), 869-74.  PMID:  24300544  

Hamlyn, E., Stöhr, W., Cooper, D.A., Fisher, M., Tambussi, G., Schechter, M., Miro, J.M., Vanobberghen, F., Babiker, A., Weber, J., McClure, M., Porter, K., Fidler, S. & SPARTAC Investigators (2015) The effect of short-course antiretroviral therapy initiated in primary HIV-1 infection on interleukin-6 and D-dimer levels. AIDS, 29 (11), 1355-61.  PMID: 25870986  

Herath, S., Le Heron, A., Colloca, S., Bergin, P., Patterson, S., Weber, J., Tatoud, R. & Dickson, G. (2015) Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag-pol-nef antigen.  Vaccine, 33(51), 7283-9.  PMID:  26546736  

Herath, S., Le Heron, A., Colloca, S., Patterson, S., Tatoud, R., Weber, J. & Dickson, G. (2016) Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors. Vaccine, 34(37), 4378-85. PMID: 27452864  

Hoehn, K.B., Gall, A., Bashford-Rogers, R., Fidler, S.J., Kaye, S., Weber, J.N., McClure, M.O., SPARTAC Trial Investigators, Kellam, P. & Pybus, O.G. (2015) Dynamics of immunoglobulin sequence diversity in HIV-1 infected individuals. Philosophical Transactions of the Royal Society B, 370, 20140241. PMID: 26194755  

Hurst, J., Hoffmann, M., Pace, M., Williams, J.P., Thornhill, J., Hamlyn, E., Meyerowitz, J., Willberg, C., Koelsch, K.K., Robinson, N., Brown, H., Fisher, M., Kinloch, S., Cooper, D.A., Schechter, M., Tambussi, G., Fidler, S., Babiker, A., Weber, J., Kelleher, A.D., Phillips, R.E. & Frater, J. (2015) Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun, 6:8495.  PMID:  26449164  

Jentsch, U., Lunga, P., Lacey, C., Weber, J., Cairns, J., Pinheiro, G., Joseph, S., Stevens, W. & McCormack, S. (2012) The implementation and appraisal of a novel confirmatory HIV-1 testing algorithm in the microbicides development programme 301 trial (MDP301). PLoS ONE, 7 (9),  e42322.  PMID: 22984401  

Joachim, A., Bauer, A., Joseph, S., Geldmacher, C., Munseri, P.J., Aboud, S., Missanga, M., Mann, P., Wahren, B., Ferrari, G., Polonis, V.R., Robb, M.L., Weber, J., Tatoud, R., Maboko, L., Hoelscher, M., Lyamuya, E.F., Biberfeld, G., Sandström, E., Kroidl, A., Bakari, M., Nilsson, C. & McCormack, S. (2016) Boosting with subtype C CN54rgp140 protein adjuvanted with glucopyranosyl lipid adjuvant after PRIMING with HIV-DNA and HIV-MVA is safe and enhances immune responses: a phase I trial PLoS One 11(5):e0155702. PMID:  27192151  

Knudsen, M.L., Ljungberg, K., Tatoud, R., Weber, J., Esteban, M. & Liljeström, P. (2015) Alphavirus replicon DNA expressing HIV antigens is an excellent prime for boosting with recombinant modified vaccinia ankara (MVA) or with HIV gp140 protein antigen. PLoS ONE 2015, 10 (2), e0117042.   PMID:  25643354  

May, M.T., Gill, M.J., Wittkop, L., Klein, M., Sabin, C., Harrigan, P.R., Dunn, D., Vehreschild, J.J., Rubio, R., Mocroft, A., Cavassini, M., Reiss, P., Monforte, A.D., Zangerle, R., Weber, J., et al. (2016) Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis. AIDS, 30(3), 503-13, 28 Jan 2016.  WOS: 000369307600002  

Martin, F., Castro, H., Gabriel, C., Adonis, A., Fedina, A., Harrison, L., Brodnicki, L., Demontis, M.A., Babiker, A.G., Weber, J.N., Bangham, C.R.M. & Taylor, G.P. (2012) Ciclosporin a proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis PLoS Neglected Tropical Diseases, 6 (6), e1675.  PMID: 22720101  

McKay, P.F., Cope, A.V., Mann, J.F.S., Joseph, S., Esteban, M., Tatoud, R., Carter, D., Reed, S.G., Weber, J. & Shattock, R.J. (2014) Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen. PLoS ONE,9 (1), e84707.   PMID:  24465426  

McKay, P.F., Cope, A.V., Swales, J., Joseph, S., Esteban, M., Tatoud, R., Carter, D., Weber, J., Shattock, R.J. (2012) Antigen-specific T lymphocyte responses elicited by a DNA - MVA HIV CN54gp140 immunization regime are significantly altered by the TLR4 adjuvant GLA Retrovirology, 9, 1-13.  WOS: 000309472100066  

Roberts, H.E., Hurst, J., Robinson, N., Brown, H., Flanagan, P., Vass, L., Fidler, S., Weber, J., Babiker, A., Phillips, R.E., McLean, A.R., Frater, J. & SPARTAC trial investigators (2015) Structured observations reveal slow HIV-1 CTL escape. PLoS Genetics, 11(2), e1004914.  PMID:  25642847  

Schmidt, C., Smith, C., Barin, B., Bakhtyari, A., Bart, P.A., Bekker, L.G., Chomba, E., Clumeck, N., Ho, D., Hoosen, A., Jaoko, W., Kaleebu, P., Karita, E., Keefer, M.C., van Lunzen, J., McMichael, A., Mehendale, S., Peters, B., Ramanathan, V., Robinson, A., Rockstroh, J., Vardas, E., Vets, E., Weber, J., Graham, B.S., Than, S., Excler, J.L., Kochhar, S., Ho, M. & Heald, A. (2012) Fast PE background morbidity in HIV vaccine trial participants from various geographic regions as assessed by unsolicited adverse events. Hum Vaccines Immunother,8 (5) 01.  PMID: 22634443  

Stoehr, W., Fidler, S., McClure, M., Weber, J., Cooper, D., Ramjee, G., Kaleebu, P., Tambussi, G., Schechter, M., Babiker, A., Phillips, R.E., Porter, K. & Frater, J. (2013) Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy.  PLoS ONE, 8(10), e78287.  PMID:  24205183  

SPARTAC Trial Investigators: Fidler, S., Porter, K., Ewings, F., Frater, J., Ramjee, G., Cooper, D., Rees, H., Fisher, M., Schechter, M., Kaleebu, P., Tambussi, G., Kinlock, S., Miro, J.M., Kelleher, A., McClure, M., Kaye, S., Gabriel, M., Phillips, R., Weber, J.* & Babiker, A.* (* Joint senior authors) (2013) The effect of short-course antiretroviral therapy in primary HIV infection: final results from SPARTAC, an international randomized controlled trial. New England Journal of Medicine, 368(3), 207-17.  PMID: 23323897  

Thornhill, J., Inshaw, J., Kaleebu, P., Cooper, D., Ramjee, G., Schechter, M., Tambussi, G., Fox, J., Samuel, M., Miro, J.M., Weber, J., Porter, K. & Fidler, S. (2016) Enhanced normalisation of CD4/CD8 ratio with earlier antiretroviral therapy at primary HIV infection. J Acquir Immune Defic Syndr, Apr. PMID: 27070122  

Weber, J., Porter, K. & Babiker, A. (2013) Short-course antiretroviral therapy in primary HIV infection.  New England Journal of Medicine, 368 (21), 2036-7.   PMID: 23697518  

White, P., Fox, J., MacDonald, N., Weber, J., McClure, M., Fidler, S. & Ward, H. (2011) How many infections are averted by behaviour change after early HIV diagnosis & counselling of MSM?  Estimates from a Stochastic individual–based model. Sexually Transmitted Infections, 87, A51-A52.  WOS: 000302874200129    

Williams, J.P., Hurst, J., Stöhr, W., Robinson, N., Brown, H., Fisher, M., Kinloch, S., Cooper, D., Schechter, M., Tambussi, G., Fidler, S., Carrington, M., Babiker, A., Weber, J., Koelsch, K.K., Kelleher, A.D., Phillips, R.E. & Frater, J., on behalf of the SPARTAC Trial Investigators (2014) HIV-1 DNA predicts disease progression and post-treatment virological control. Elife, 10.7554/eLife.03821.  PMID:  25217531  

Yager, N, Robinson, N, Brown, H, Flanagan, P, Frater, J, Fidler, S, Weber, J, Phillips, R, the SPARTAC Trial Investigators (2013) Longitudinal analysis of an HLA-b*51-restricted epitope in integrase reveals immune escape in early HIV-1 infection. AIDS, 27 (3), 313-23.  PMID:  23095315