Dr Deepa Jayakody Arachchillage Consultant haematolgist (haemostaisis and thrombosis)

Background

Dr Deepa Jayakody Arachchillage trained in medicine at the North Colombo University in Sri Lanka and trained in haematology at the Newcastle Upon Tyne University Hospitals and University College London (UCL). She was awarded an MD (res) from UCL in July 2015 following successful completion of research related to antiphospholipid syndrome (APS), complement activation and direct acting oral anticoagulants. She has published in many peer reviewed journals and written several book chapters in the field. She has presented in a number of national and international conferences. She has been a co-investigator for several clinical trials and received funding for research projects. Dr Jayakody Arachchillage is a member of the British Society of Haematologists' haemostasis and thrombosis task force. She has a specialised clinic for patients with APS at Hammersmith Hospital every Friday.

Expertise

Antiphospholipid syndrome, thrombosis and acquired bleeding disorders, congenital bleeding disorders

Research & publications

Dr Jayakody Arachchillage's principal research interests are antiphospholipid syndrome (APS), anticoagulation and acquired bleeding disorders mainly related to cardiac surgeries and extra corporeal membrane oxygenation (ECMO) in both children and adults.

Recent publications:

Cohen, H., Arachchillage, D.R., Middeldorp, S., Beyer-Westendorf, J. & Abdul-Kadir, R. (2016) Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH: reply. J Thromb Haemost, Oct 12. doi: 10.1111/jth.13535. [Epub ahead of print]

Arachchillage, D.R.J., Reynolds, R., Devey, T., Maclean, R., Kitchen, S. & van Veen. J.J. (2016) Effect of extremes of body weight on drug level in patient treated with standard dose of rivaroxaban for venous thromboembolism; real life experience. Thromb Res, Sep 14, 147, 32-35. doi: 10.1016/j.thromres.2016.09.010. [Epub ahead of print]

Cohen, H., Hunt, H.J., Efythymiou, M., Arachchillage, D.R.J., Mackie, I.J., Muirhead, N., Clawson, S., Sylvestre, Y., Machin, S., Bertolaccini, M.L., Ruiz, M., Samuel, J., Machin, Dore', C.J., Khamashta, M., Isenberg, D.A. & RAPS trial investigators (2016) Rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE (RAPS): a randomised, controlled, open-label, phase 2/3, non-inferiority trial. Lancet Haematol, 3, e426-36.

Cohen, H., Arachchillage, D.R., Beyer-Westendorf, J., Middeldorp, S. & Kadir, R.A. (2016) Direct oral anticoagulants and women. Semin Thromb Hemost, Oct, 42(7),789-97. Epub 2016 Oct 5.

Arachchillage, D.R.J, Mackie, I.J., Efthymiou, M., Chitolie, A., Hunt, B.J., Isenberg, D.A., Khamashta, M., Machin, S.J. & Cohen, H. (2016) Rivaroxaban limits complement activation compared to warfarin in antiphospholipid syndrome patients with venous thromboembolism. J Thromb Haemost.

Beyer-Westendorf, J., Michalsk, F., Tittl, L., Middeldorp, S., Cohen, H., Middeldorp, S., Abdul-Kadir, R., Arachchillage, D.R.J., et al. (2016) Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting. Thromb Haemost, Jul 7, 116(3). [Epub ahead of print]

Cohen, H., Arachchillage, D.R.J., Middeldorp, S., Beyer-Westendorf, J. & Abdul-Kadir, R. (2016) Management of direct oral anticoagulants in women of childbearing potential: guidance from the international society on thrombosis and haemostasis. J Thromb Haemost, 14, 1673-6.

Arachchillage, D.R., Besser, M., Maclean, R., Baglin, T. & van Veen, J.J. (2016) Combined factor IIa and Xa inhibitor therapy for thrombosis whilst on therapeutic anticoagulant. Thromb Res, 143, 137-40.

Arachchillage, D.R.J. & Makris, M. (2015) Choosing and using non-steroidal anti-inflammatory drugs in haemophilia. Haemophilia, Nov 4. doi: 10.1111/hae.12805. [Epub ahead of print]

Arachchillage, D.R.J., Mackie, I.J., Efthymiou, M., Isenberg, D.A., Machin, S.J. & Cohen, H. (2015) Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome. J Thromb Haemost, 13, 1264-73

Efthymiou, M., Lawrie, A.S., Mackie, I.J., Arachchillage, D.R.J., Lane, P., Machin, S.J. & Cohen, H. (2015) Thrombin generation and factor X assays for the assessment of warfarin anticoagulation in thrombotic antiphospholipid syndrome. Thromb Res, 135, 1191-7

Arachchillage, D.R., Efthymiou, M., Mackie, I.J., Lawrie, A.S., Machin, S.J. & Cohen, H. (2015) Rivaroxaban and warfarin achieve effective anticoagulation, as assessed by inhibition of TG and in-vivo markers of coagulation activation, in patients with venous thromboembolism. Thromb Res, 135, 388-93

Arachchillage, D.R., Machin, S.J. & Cohen, H. (2015) Heparin-induced thrombocytopenia following plasma exchange in patients with demyelinating neurological disease. Int J Lab Hematol, 37, 75-7

Arachchillage, D.R., Machin, S.J., Mackie, I.J. & Cohen, H. (2015) Diagnosis and management of non-criteria obstetric antiphospholipid syndrome. Thromb Haemost, 113, 13-9

Arachchillage, D.R., Efthymiou, M., Mackie, I.J., Lawrie, A.S., Machin, S.J. & Cohen, H. (2014) Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome. J Thromb Haemost, 12, 1801-9

Arachchillage, D.R., Efthymiou, M., Lawrie, A.S., Machin, S.J., Mackie, I.J. & Cohen, H. (2014) Comparative sensitivity of commonly used thromboplastins to ex vivo therapeutic rivaroxaban levels. Thromb Haemost, 112, 421-3

Arachchillage, D.J., Greaves, M. (2014) The chequered history of the antiphospholipid syndrome. Br J Haematol, 165, 609-17

Jayakody Arachchillage, D., Hurst, E., Carey, P., Moses, S., O'Brien, S.G., Menne, T., et al. (2014) Haemophagocytic lymphohistiocytosis following fludarabine/cyclophosphamide chemotherapy for chronic lymphocytic leukaemia. Br J Haematol,166, 142-5.

Jayakody Arachchillage, D.R., Machin, S.J. & Cohen, H. (2014) Antithrombotic treatment for stroke associated with antiphospholipid antibodies. Expert Rev Hematol, 7, 169-72

Arachchillage, D.R.J., Cohen, H. (2014) Antiphospholipid syndrome. Medicine, 42, 156-61

Arachchillage, D.J. & Cohen, H. (2013) Use of new oral anticoagulants in antiphospholipid syndrome. Curr Rheumatol Rep, 15, 331-9

Book chapters:

Arachchillage, D.R.J., Davie, C.A. & O'Brien, P. (2015) Management of stroke during pregnancy. Disorders of Thrombosis and Haemostasis in Pregnancy, Springer

Arachchillage, D.R.J. & Hillmen, P. (2015) Paroxysmal nocturnal haemoglobinuria in pregnancy. Disorders of Thrombosis and Haemostasis in Pregnancy, Springer

Arachchillage, D. & Cohen, H. (2015) Antiphospholipid syndrome - a multisystem disease. Cerebrovascular Disease, Springer