Dr Channa Jayasena Consultant in reproductive endocrinology and andrology

Background

Dr Channa Jayasena is clinical senior lecturer at Imperial College London and consultant in reproductive endocrinology and andrology at Hammersmith and St Mary’s hospitals. Dr Jayasena qualified in medicine at Cambridge University, after which he undertook specialist training in diabetes and endocrinology in London, and performed research at Imperial College as a Wellcome Trust clinical research training fellow and subsequently NIHR clinical lecturer. Dr Jayasena leads a research group at Imperial College which aims to develop new treatments for men and women with reproductive disorders.

Dr Jayasena has received several national and international awards, including the prestigious 2014 Young Endocrinologist Prize Lecture, the highest honour to be given to a trainee clinician by the UK’s Society for Endocrinology (SFE). Dr Jayasena has national expertise in the treatment of reproductive disorders, and is regularly invited to update other doctors on the treatment of reproductive disorders. Dr Jayasena regularly comments on new developments in the field. The overarching aim of his practice is to provide the best treatment possible for his patients, and provide state-of-the-art therapies to benefit all patients and couples in the future. 

Expertise

Male infertility, female infertility, hormone replacement therapy (HRT), testosterone, androgens, polycystic ovarian syndrome, hypothalamic amenorrhoea, puberty disorders, azoospermia, DNA fragmentation, sperm disorders, menopause, hot flushes, oestrogen

Research & publications

Dwyer, A.A., Jayasena, C.N. & Quinton, R. (2016) Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty. Minerva Endocrinol. Jun, 41(2), 188-95. 

 

Narayanaswamy, S., Jayasena, C.N., Ng, N., Ratnasabapathy, R., Prague, J.K., Papadopoulou, D., Abbara, A., Comninos, A.N., Bassett, P., Bloom, S.R., Veldhuis, J.D. & Dhillo, W.S. (2016) Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels. Clin Endocrinol (Oxf). Jun, 84(6), 939-45. 

 

Clarke. H., Dhillo, W.S. & Jayasena, C.N. (2015) Comprehensive review on kisspeptin and its role in reproductive disorders. Endocrinol Metab (Seoul). Jun, 30(2), 124-41

 

Abbara, A., Jayasena, C.N., Christopoulos, G., Narayanaswamy, S., Izzi-Engbeaya, C., Nijher, G.M., Comninos, A.N., Peters, D., Buckley, A., Ratnasabapathy, R., Prague, J.K., Salim, R., Lavery, S.A., Bloom, S.R., Szigeti, M., Ashby, D.A., Trew, G.H. & Dhillo, W.S. (2015) Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy. J Clin Endocrinol Metab. Sep, 100(9), 3322-31. 

 

Jayasena, C.N., Abbara, A., Narayanaswamy, S., Comninos, A.N., Ratnasabapathy, R., Bassett, P., Mogford, J.T., Malik, Z., Calley, J., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2015) Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men. Hum Reprod. Aug, 30(8), 1934-41. 

Comninos, A.N., Anastasovska, J., Sahuri-Arisoylu, M., Li, X., Li, S., Hu, M., Jayasena, C.N., Ghatei, M.A., Bloom, S.R., Matthews, P.M., O'Byrne, K.T., Bell, J.D. & Dhillo, W.S. (2015) Kisspeptin signalling in the amygdala modulates reproductive hormone secretion. Brain Struct Funct. epub Mar 11. 

Jayasena, C.N., Comninos, A.N., Stefanopoulou, E., Buckley, A., Narayanaswamy, S., Izzi-Engbeaya, C., Abbara, A., Ratnasabapathy, R., Mogford, J., Ng, N., Sarang, Z., Ghatei, M.A., Bloom, S.R., Hunter, M.S. & Dhillo, W.S. (2015) Neurokinin B administration induces hot flushes in women. Scientific Reports (Nature Publishing Group) 16(5),8466.  

Jayasena, C.N., Abbara, A., Izzi-Engbeaya, C., Comninos, A.N., Harvey, R.A., Gonzalez Maffe, J., Sarang, Z., Ganiyu-Dada, Z., Padilha, A.I., Dhanjal, M., Williamson, C., Regan, L., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2014) Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage. J Clin Endocrinol Metab. Dec, 99(12), E2652-60.  

Jayasena, C.N., Izzi-Engbeaya, C., Narayanaswamy, S., Modi, M., Clarke, H., Nijher, G.M., Meeran, K. & Dhillo WS. (2014) Associations of coefficient of variation of serum GH with previous radiotherapy, hypopituitarism and cardiac disease in patients with treated acromegaly. Clin Endocrinol (Oxf). e-pub ahead of print Dec 1 

Jayasena, C.N., Abbara, A., Comninos, A.N., Nijher, G.M.K., Christopoulos, G., Narayanaswamy, S., Izzi-Engbeaya, C., Sridharan, M., Mason, A., Warwick, J., Ashby, D., Ghatei, M.A., Bloom, S.R., Carby, A., Trew, G. & Dhillo, W.S. (2014) Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation. 124(8), 3667-77.  

Jayasena, C.N., Comninos, A.N., Narayanaswamy, S., Abbara, A., Nijher, G.M., Cheema, M., Malik, Z., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2015) The identification of elevated urinary kisspeptin immunoreactivity during pregnancy. Ann Clin Biochem. May;52(Pt 3), 395-398. 

Jayasena, C.N. & Franks, S. (2014) The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol. Oct, 10(10), 624-36. 

Jayasena, C.N., Comninos, A.N., Narayanaswamy, S., Bhalla, S., Abbara, A., Ganiyu-Dada, Z., Busbridge, M., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2014) Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy women. Clinical Endocrinology. 81(6), 891-8.  

Jayasena, C.N., Abbara, A., Veldhuis, J.D., Comninos, A.N., Ratnasabapathy, R., De Silva, A., Nijher, G.M., Ganiyu-Dada, Z., Mehta, A., Todd, C., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2014) Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54. J Clin Endocrinol Metab. 99(6), E953-61 

Comninos, A.N., Jayasena, C.N. & Dhillo, W.S. (2014) The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update. 201(20), 153-74. 

Jayasena, C.N., Comninos, A.N., De Silva, A., Abbara, A., Veldhuis, J.D., Nijher, G.M.K, Ganiyu-Dada, Z., Vaal, M., Stamp, G., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2014) Effects of neurokinin B administration on reproductive hormone secretion in healthy men. Journal of Clinical Endocrinology & Metabolism. Jan, 99(1), E19-27.  

Jayasena, C.N., Comninos, A.N., Nijher, G.M.K., Abbara, A., De Silva, A., Veldhuis, J.D., Ratnasabapathy, R., Izzi-Engbeaya, C., Lim, A., Patel, D.A., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2013) Twice-daily subcutaneous injection of kisspeptin-54 does not abolish menstrual cyclicity in healthy female volunteers. Journal of Clinical Endocrinology & Metabolism. Nov, 98(11), 4464-74. 

Jayasena, C.N. et al. (2013) Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults. Annals of Clinical Biochemistry Jan, 51(Pt 1), 89-96.

Jayasena, C.N. et al. (2013) A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women. Clinical Endocrinology Oct, 79(4), 558-63.  

Beale, K.E.L., Gardiner, J.V., Bewick, G.A., Hostomska, K., Patel, N.A., Hussain, S.S., Jayasena, C.N. et al. (2013) Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. British Journal of Clinical Pharmacology. 168, 403-10. 

Abbara, A., Ratnasabapathy, R., Jayasena, C.N. & Dhillo, W.S. (2013) The effects of kisspeptin on gonadotropin release in non-human mammals. Adv Exp Med Biol. 784, 63-87.  

Jayasena, C.N., Comninos, A., Veldhuis, J., Misra, S., Abbara, A., Izzi-Engbeaya, C., Donaldson, M., Ghatei, M., Bloom, S. & Dhillo, W. (2013) A single injection of kisspeptin-54 temporarily increases LH pulsatility in healthy women. Clin Endocrinol (Oxf). e-pub Mar 2.  

Suzuki, K., Jayasena, C.N. & Bloom, S.R. (2012) The gut-brain axis. Experimental Diabetes Research. In press.  

Jayasena, C.N., Comninos, A.N., Januszewski, A., Gabra, H., Taylor, A., Harvey, R.A., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2012) Plasma kisspeptin: a potential biomarker of tumor metastasis in patients with ovarian carcinoma. Clin Chem. 58(6),1061-3 

Jayasena, C.N., Nijher, G.M., Comninos, A.N., Abbara, A., Januszewki, A., Vaal, M.L., Sriskandarajah, L., Murphy, K.G., Farzad, Z., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S.. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. Journal of Clinical Endocrinology & Metabolism 96(12), E1963-72 

Suzuki, K., Jayasena, C.N. & Bloom, S.R. (2011) The gut hormones in appetite regulation. J Obes., 2011, 528401.  

Jayasena, C.N., Comninos, A.N., Clarke, H., Donaldson, M., Meeran, K. & Dhillo, W.S. (2011) Associations of total GH and IGF-1 exposure with cardiovascular, cerebrovascular and metabolic co-morbidities in patients with treated acromegaly. Clinical Endocrinology. 75(2), 220-5 

Jayasena, C.N., Mohammad, M., Fausto, F., Donaldson, M., Meeran, K. & Dhillo, W.S. (2011) Utility of the urine calcium to creatinine ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcemic patients with vitamin D deficiency. Annals of Clinical Biochemistry. 48(Pt 2), 126-9.  

Jayasena, C.N., Nijher, G.M.K., Abbara, A., Murphy, K.G., Lim, A., Patel, D., Mehta, A., Todd, C., Donaldson, M., Trew, G., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2010) Twice-weekly administration of kisspepeptin-54 for eight weeks stimulates reproductive hormone release in women with hypothalamic amenorrhoea. Clinical Pharmacology & Therapeutics. 88(6), 840-7. 

Hameed, S., Jayasena, C.N. & Dhillo, W.S. (2010) Kisspeptin and fertility. Journal of Endocrinology. 208(2), 97-105

Jayasena, C.N. & Dhillo, W.S. (2010) Neurokinin B and kisspeptin – sexual partners or single agents? Endocrinology, 51, 4090-1 

Logan, S., Jayasena, C., Aali, A., Ash, S. & Cooke, F.J. (2010) Typhoid without travel. Clin Med. Jun, 10, 299-300.

Nijher, G.M.K, Baxter, J.E., Chaudhri, O.B., Murphy, K.G., Ramachandran, R., Fowler, A., Chinthapalli, K., Patterson, M., Jayasena, C.N., Williamson, C., Kumar, S., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2010) The identification of the novel hormone kisspeptin in amniotic fluid. Clinical Chemistry. 56(6), 1029-31. 

Jayasena, C.N., Nijher, G.K., Chaudhri, O.B., Murphy, K.G., Ranger, A., Lim, A., Patel. D, Mehta, T.C., Ramachandran, R., Salem, V., Stamp, G., Donaldson, M., Ghatei, M.A., Bloom, S.R. & Dhillo, W.S. (2009) Subcutaneous injection of Kisspeptin-54 acutely stimulates gonadotrophin secretion in women with hypothalamic amenorrhea but repeated administration leads to tachyphylaxis. Journal of Clinical Endocrinology & Metabolism. 94(11), 4315-23

Jayasena, C.N., Dhillo, W.S. & Bloom, S.R. (2009) Does kisspeptin signaling offer a novel therapeutic target for infertility? Expert Review in Obstetrics & Gynaecology, 4(5), 477-481 

Jayasena, C.N., Tharakan, G. & Dhillo, W.S. (2009) Kisspeptin: paving the way to a new therapeutic avenue in reproduction. Recent Patents on Endocrine, metabolic & Immune Drug Discovery. 3(2):87-93.

Jayasena, C.N. & Dhillo, W.S. (2009) Kisspeptin offers a novel therapeutic target in reproduction. Curr Opin Investig Drug. 10(4), 311-8. 

Jayasena, C.N., Gadhvi, K.A., Makwana, B., Martin, N.M., Mendoza, N., Meeran, K. & Dhillo, W.S. (2009) A single early morning cortisol in the immediate post-operative period following transphenoidal surgery for pituitary tumours accurately predicts hypothalamo-pituitary-adrenal function. Clinical Chemistry. 55(5), 972-7 

Jayasena, C.N., Dhillo, W.S., Bloom, S.R. (2009) Kisspeptins and the control of gonadotrophin secretion in humans. Peptides. 30(1), 76-82 

Gardiner, J.V., Jayasena, C.N. & Bloom, S.R. (2008) Gut hormones: a weight off your mind. Journal of Neuroendocrinology. 20(6), 834-41. 

Jayasena, C.N., Ranger, A. & Dhillo, W.S. (2008) Kisspeptin – from puberty to pregnancy. Biologist. 55(2). 

Jayasena, C.N. & Bloom, S.R. (2008) Role of gut hormones in obesity. Endocrinology and Metabolism Clinics of North America. 37(3), 769-87. 

Jayasena, C.N., Wujanto, C., Donaldson, M., Todd, J.F. & Meeran, K. (2008) Measurement of Basal growth hormone (GH) is a useful test of disease activity in treated acromegalic patients. Clinical Endocrinology. 68, 36-41.

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